Research Overview

 Conquer Chiari takes every dollar it receives in donations very seriously. In order to maximize the impact of your donations, Conquer Chiari has established a Research Agenda, and a structured research program to achieve it.

The Research Agenda lays out the Goals and Objectives which, when achieved, will go a long way towards Conquering Chiari. To accomplish this, Conquer Chiari established the Conquer Chiari Research Center at the University of Akron (CCRC). The CCRC acts as the focal point for Chiari research and has quickly built a reputation as the premier Chiari research institution in the world.

In addition, to organize and structure our funding of projects, Conquer Chiari has launched several Research Programs:
  1. Quantitative Measures (11 projects, $799,000 funded, $500,000 external grant)
    Program Advisor: Dr. Francis Loth

  2. Pathophysiology (10 projects, $642,000 funded)
    Program Advisor: Dr. Francis Loth

  3. Infrastructure (6 projects, $1,773,000 funded)
    Program Advisor: Rick Labuda

  4. Quality of Life (3 projects, $200,000 funded)
    Program Advisor: Dr. Phil Allen

If you are a scientist or medical professional interested in Chiari research and have a project you would like to discuss, please call Rick Labuda at 724-940-0116 or email:  director@conquerchiari.org

Goal 1:   Reduce the average time to an accurate diagnosis to less than 3 months from time of first symptoms.

 Objectives:

  • Develop a standard, simple, objective definition and test of symptomatic Chiari
  • Enable the introduction of new technologies, such as inexpensive, portable imaging, which will reduce the barriers to diagnosis

Goal 2:   Develop an effective, widely adopted, and minimally traumatic standard of care.

 Objectives:

  • Design, and encourage the adoption of, a standard outcome measure, such that the results from different studies can be compared and combined
  • Establish whether the surgical variations that currently exist have a significant effect on long-term patient outcomes, and further develop a standardized surgical approach
  • Encourage the development of minimally invasive surgical techniques
  • Pursue non-surgical treatment approaches which don't just address symptoms, but are targeted at the core problem(s)

Goal 3:   Minimize the impact that Chiari has on the quality of life of patients.

 Objectives:

  • Develop, and encourage the adoption of, a Chiari Impact Measure, which takes into account patient focused issues such as career, family, economics, recreation, and socialization
  • Understand, and develop treatments for, the neuropsychological effects of Chiari, including both cognitive and emotional manifestations
  • Develop widely accepted protocols for physical, occupational, and other types of therapies designed to maximize functional capabilities
  • Enable the development of innovative technologies and treatments targeted at the neuropathic pain and loss of function associated with Chiari

Goal 4:   Understand the pathophysiology, natural history, and epidemiological characteristics of Chiari.

 Objectives:

  • Establish, with reasonable accuracy, the incidence and prevalence of Chiari and Chiari related syringomyelia
  • Characterize, and quantify, the Chiari experience, such as average age of diagnosis, time to diagnosis, number of doctors seen, major symptoms, etc.
  • Develop a sound theoretical model for the pathophsyiology of Chiari, which explains how symptoms develop, and will enable predictions about who needs surgery, who will develop syringomyelia, etc.
  • Identify and characterize the genetic basis of Chiari

Why It's Important

One of the primary challenges of Chiari is the lack of objective tests and measures. While Chiari is defined by the degree of cerebellar tonsillar herniation, it has been shown that this is not a strong measure of symptom severity or eventual treatment outcome. Further complicating the picture is the fact that many Chiari symptoms can be vague and subjective. Developing objective, quantitative measure of Chiari and its symptoms would be a tremendous advance for patients.

Goal

Develop accurate and reliable quantitative measures and markers of Chiari presence and severity, allowing the ability to:

  • provide a faster, more accurate diagnosis
  • objectively assess symptom severity
  • objectively assess surgical success/failure
  • objectively assess the effectiveness of new treatments
  • classify patients into sub-groups
  • contribute to the fundamental understanding of Chiari

Active Projects (6)

Measuring brain displacement with DENSE MRI in patients with Chiari Malformation | $54,000
Dr. John Oshinski

Dr. John Oshinski, working with researchers at the CCRC will use a new type of MRI scan, DENSE, to measure the actual movement of brain tissue in Chiari patients as compared to healthy controls. Once the tissue movement is captured, the strain being placed on the brains of Chiari patients can be determined and mapped. This could be a valuable diagnostic too.
Automated Morphometric Analysis for Diagnosis & Research | $49,783 (Year One), $86,505 (Year Two)
Dr. Francis Loth

The goal of this project is to develop semi and fully automated techniques to quantify MR based morphometric measurements. Fully automating these measurements would have an enormous research and potentially clinical impact.
Morphometrics | Part of Chiari1000
Dr. Francis Loth

The CCRC team will use the MRI’s and other data collected from the Chiari 1000 project to identify unique features of the skull and brains of Chiari patients. They hope to develop useful clinical parameters (beyond tonsillar herniation) and also to shed light on gender differences in Chiari and differences between pediatric and adult onset Chiari.

Cough Associated Changes in CSF Flow in CMI Evaluated by Real-Time MRI | $24,200
Dr. Rafeeque Bhadelia

With this project Dr. Bhadelia continues his work in using real time MRI as a way to quantitatively assess symptomatic Chiari. He hopes to show that after coughing, CM patients have a distinct pattern of spinal fluid flow the junction between the skull and spine.

Brain Damage in Chiari 1 Malformation | $142,000
Dr. Phil Allen

Dr. Allen (CCRC) is working to understand how damage to brain tissue occurs in Chiari and the cognitive and/or emotional impacts this damage may impart. This project utilizes detailed psychological tests (32-lead electroencephalogram and others) and MRI diffusion tensor imaging and brain motion analysis tools to quantify brain damage in Chiari. This interdisciplinary study is being conducted in partnership with Cleveland Clinic Foundation (Stephen Dombrowski PhD and Mark Luciano PhD, MD) and Vanderbilt University (Seth Smith, PhD). Results from this study will help to identify the location of damage that occurs in Chiari and new information about the specific neural circuits involved.

Metabolic and Inflammatory Alterations in Patients with Chiari Malformation | $60,000
Dr. Leah Shriver

Many neurological conditions, such as MS, have been shown to involve significant changes in brain metabolism with indications of an inflammatory response. Dr. Leah Shriver, a professor in the Department of Chemistry and Biology at the University of Akron, is exploring her hypothesis that Chiari patients, due to the tonsillar herniation and disrupted flow of cerebrospinal fluid (CSF) will show significant alterations in the metabolic profile associated with the central nervous system. Dr. Shriver is an expert in metabolomics and has studied the metabolic response associated with MS.

Completed Projects (5)

Physiology-based Quantitative Assessment of CSF Flow Obstruction at the Foramen Magnum in Patients with Chiari I Malformation | $30,000
Dr. Rafeeque Bhadelia

Dr. Bhadelia (Beth Israel Deaconess Medical Center) conducted a pilot study to quantitatively assess the degree of CSF flow obstruction at the foramen magnum in patients with Chiari I malformation (CM) using fast CSF flow imaging with MRI and physiological challenges such as Valsalva maneuver. His findings confirmed his hypothesis that he could identify Chiari patients by the CSF flow pattern after Valsalva or cough. His results were recently published and Conquer Chiari has awarded him additional money to collect more data.

Cognitive Functioning in CM1 | $75,000
Cognitive Interventions in Children with CM1 | $75,000

Dr. David Frim

Dr. Frim and his team at the University of Chicago utilized neuropsychological testing on both children and adults and found that while overall intelligence was normal, there was a specific, identifiable pattern of weakness in certain types of verbal memory and executive function. In the children, these weaknesses improved significantly after decompression surgery, but with adults not as much. Based on these results, Dr. Frim was awarded a second grant to investigate the effects of two types of cognitive intervention therapies designed to improve working memory and attention (one computer based and one based on more traditional face-to-face therapy) on neurocognitive performances of children diagnosed with CM1. Their hypothesis was that CM1 patients with below average executive function and memory would show improvement in those functions after one or both of the intervention. The results are being analyzed and prepared for publication.

MRI Based Classification of Chiari Malformation | $33,000
Dr. Malena Espanol
 

Dr. Espanol (U of Akron) applied what is known as Machine Learning to the problem of objectively diagnosing Chiari. Basically, the idea was to input a large amount of data - in this case morphometric measurements from the MRIs of Chiairi patients and healthy controls - into a computer analysis, so the computer can learn how to distinguish between symptomatic and asymptomatic Chiari. Dr. Espanol's preliminary results were encouraging and identified a few morphometric measurements as potentially very significant. This project will continue by analyzing the much larger dataset from the Chiari 1000 project.
Dynamic MRI and Quantitative MR CSF Flow Studies in Chiari I Malformations | $50,000
Dr. Rajeev Bapuraj  

Dr. Bapuraj (U of Michigan) studied the effect of neck position on tonsillar crowding and CSF flow in children with Chiari. While he didn't find any significant data in this regard, as often happens with research, he did observe some interesting dynamics and is currently working on a publication.

Hydrodynamics of Chiari | $120,000
Dr. Frank Loth

Dr. Loth (CCRC used advanced MRI and engineering techniques to measure 3 different hydrodynamic parameters in symptomatic Chiari patients, asymptomatic Chiari patients, and healthy controls. Their work produced strong enough preliminary results that Dr. Loth was arded a $500,000 NIH grant to continue and expand this line of research, with the goal of providing objective, quantitative data to aid in Chiari diagnosis. The most promising result showed that Longitudinal Impedance, a measure of the resistance to CSF flow in the spine, is significantly different between Chiari patients and healthy people, and may also be able to discriminate between symptomatic Chiari and asymptomatic tonsillar herniation.

Why It's Important

Pathophysiology refers to the study of the physical manifestation of a disease in a person. In other words, what is wrong and why. Understanding the pathophysiology of Chiari should address important questions such as:

  • Are pediatric and adult Chiari the same or different?
  • Why are more women affected than men?
  • Why do symptoms vary so much from person to person?
  • What causes symptoms to start in the first place?
  • Why do people respond differently to treatment?

Understanding the pathophysiology of Chiari is critical to advancing the care that patients receive. Unfortunately, studying the pathophysiology of a disease involves work in basic science, which is expensive, takes a long time to develop, and is high risk.

Goal

Develop a complete, practical, and accurate disease model of Chiari, which would answer fundamental questions, enable the categorization of patients, and suggest new techniques for diagnosis and treatment.

Active Projects (5)

Biomechanical Assessment of Brain Deformation in Chiari Malformation | $40,326
Dr. Rouzbeh Amini

Based on the data collected by Dr. Oshinski using DENSE scans, Dr. Amini will perform a biomechanical analysis to determine the forces that the brains of Chiari patients are exposed to. This may provide clues as to the underlying causes of Chiari and the link to specific symptoms.
Identification of novel MRI parameters and genetic factors for the diagnosis of classical Chiari | $47,179
Dr. Allison Ashley-Koch

Using samples acquired through the Chiari 1000, Dr. Ashley-Koch will perform targeted genetic sequencing looking for known connective tissue genetic variants among Chiari patients.
Targeting Syrinx Transporters for Syringomyelia Treatment Strategies | $128,275
Dr. Nic Liepzig

With this project, Dr. Liepzig’s team will continue their work in understanding syrinxes at the cellular level (using a rat model) and work to identify compounds that may slow or stop syrinx growth.
Biomarkers of surgical success in females with Chiari Malformation Type I | Part of Chiari1000
Dr. Phil Allen

A key part of the Chiari 1000 project, Dr. Phil Allen and his team will try to explain some of the variation in surgical outcomes among adult women. Specifically they will look at hormone levels to identify markers of an altered stress response which could account for why so many patients do not improve even after what is considered a medically successful surgery.
Genetic Traits of CM Across Age and Gender | Part of Chiari1000
Dr. Aintzane Urbizu

As part of the larger Chiari 1000 project, Dr. Urbizu, a visiting researcher from Europe, is collecting saliva samples from Chiari 1000 participants in order to look for genetic factors that are associated with specific skull and brain features commonly found in Chiari.

Completed Projects (5)

Molecular Biology Assessment of Syringomyelia | $97,000
Dr. Nic Leipzig

Dr. Liepzig is conducting research into nerve damage and healing, specifically looking at the molecular processes that are involved in syringomyelia. In this project, Dr. Liepzig successfully created a syringomyelia model in rats and was able to analyze the molecular processes associated with syrinx growth. Based on these published results, Conquer Chiari has funded Phase II of this work which will begin to look at ways to reduce or reverse the processes which lead to so much damage associated with syrinxes.
Cellular and Molecular Processes Affecting Posterior Fossa Volume (Phase III) | $150,000
Dr. Georgy Koentges

Dr. Koentges' team made tremendous strides in identifying the underlying mechanisms involved in the development of the bony structures that are affected in classical Chiari. Through painstaking work which followed the fate of specific cells as mice developed, he identified some potential pathways which could explain the undersized posterior fossa in classical Chiari. His results will compared to what is found in the Morphometrics project associated with the Chiari 1000.
Molecular Neural Crest-mesoderm Interactions and Control Networks Affected in Chiari (Phase II) | $75,000
Dr. Georgy Koentges

Extending his previous project, Dr. Koentges used advanced cell fate mapping techniques to study abnormal skull base development as seen with Chiari. His work was very well received at the 2010 Conquer Chiari research conference and holds significant implications for further research.
Microarray-based discovery of genes active in post-otic neural crest at critical stages and places of head morphogenesis affected in Chiari I/II (Phase I) | $50,000
Dr. Georgy Koentges

Dr. Georgy Koentges employed a mouse model to identify what genes are active at critical stages of embryological development which are believed to correspond to when the defects associated with Chiari occur. According to Dr. Koentges, “As a direct results of this grant, our investigations into PONC cells has led to the establishment of the molecular development of the tissues implicated in the variety of symptoms of Chiari.”
Characterization of Chiari Clinical Subtypes by Expression Analysis | $54,000
Dr. Simon Gregory

Dr. Simon Gregory, a geneticist at Duke University, performed genetic analysis on pediatric Chiari patients undergoing surgery, in order to identify clinical sub-groups. Dr. Gregory examined blood and tissue samples from the patients and correlated the genetic expression(s) with clinical indicators, such as skull dimensions and the presence of a syrinx. This work developed several promising leads for further genetic research.

Why It's Important

Building an effective research program involves more than just funding individual projects. To be truly impactful for the Chiari community, top researchers – from a variety of disciplines - must be attracted to the field; easy access to patients and patient data must be established; and results must be disseminated effectively through conferences and journals.

Conquer Chiari is committed to doing more than just funding projects; we are committed to having a positive impact on patient outcomes and experiences. Therefore, we have committed a significant amount of resources to building a Chiari research environment, the centerpiece of which is the Conquer Chiari Research Center (CCRC).

The CCRC has quickly proven that our commitment to building a research infrastructure is paying dividends.

Goal

Develop the research infrastructure necessary to create a vibrant Chiari research ecosystem.

Active Projects (3)

Chiari 1000 | $368,644 (Year One), $207,205 (Year Two), $110,262 (Year Three)
Dr. Francis Loth

The Chiari 1000 is the largest project Conquer Chiari has funded to date. The goal is to collect uniform data from 1,000 Chiari patients, including demographics, medical information, neuropsychological scales, MRI’s, and for some people biological samples, such as saliva and blood. Conquer Chiari believes that by collecting data on such a large number of patients, the researchers at the CCRC will be able to make significant progress in answering key questions surrounding Chiari and have a major impact on the standard of care. The Chiari 1000 includes several sub-projects, such as morphometrics, biomarkers, and genetics. Just six months into this multi-year project, over 500 people have completed all of the on-line questionnaires and hundreds of MRIs have been received. If you are interested in participating in this ground breaking project, visit: https://chiari1000.uakron.edu/

Conquer Chiari Research Center | $743,541
Dr. Francis Loth

The CCRC is the world's first research laboratory dedicated solely to advancing the medical and scientific understanding of Chiari malformation in order to improve the experiences and outcomes of patients. The Conquer Chiari Research Center (CCRC) at the University of Akron is a state of the art facility, staffed with distinguished researchers, working diligently to: Apply the latest engineering techniques and analyses to improve diagnoses and treatment options, Leverage the Conquer Chiari Patient Registry to study the epidemiology and natural history of Chiari, Foster collaborations with leading clinicians and scientists to advance the Conquer Chiari Research Agenda and act as a focal point for the Chiari research community and attract more researchers to the study of Chiari.

Conquer Chiari Research Conference | $80,000
Dr. Francis Loth & Rick Labuda

The Conquer Chiari Research Conference is a bi-annual, professional meeting which brings together the top Chiari clinicians and scientists world-wide to present new developments in Chiari research, discuss issues, and form new collaborations.

Completed Projects (3)

Chiari Imaging Database | $48,000
Dr. Francis Loth

The CCRC has teamed with Akron General Hospital (who is offering MRI time at a greatly reduced cost) to build an MRI database of Chiari patients. The CCRC is working to establish a broad set of protocols which will be used on a wide variety of Chiari patients. The goal is to gather as much information as possible and to provide a platform for future research.

Conquer Chiari Patient Database | $125,000
Rick Labuda

Administered by Conquer Chiari itself, the Conquer Chiari Patient Database was a web based, secure database of demographic and health related information about Chiari patients. Patients entered their own data on topics ranging from diagnostic history, to surgical history, to the impact Chiari has had on their lifestyle. Information was collected on more than 1,000 patients. An interactive infographic was created to explore the results: http://registry.conquerchiari.org/

Voices of Chiari: Advancing Chiari Research Through a National Patient Registry | $90,000
Dr. Michelle Chyatte

Dr. Michelle Chyatte and her colleagues at NEOMED analyzed the data in the patient registry and generated several interesting publications from it and have presented at research conferences. In addition, they created an interactive infographic for the general public to explore the registry data (see link above).

Why It's Important

A lot of medical research involves basic science, which can take years and cost a tremendous amount of money.

The QoL research program is focused on addressing specific questions, in a timely fashion, which will directly improve patients’ daily experience. For example:

  • How can Chiari kids participation in the educational experience be maximized?
  • What therapies can be used to minimize residual symptoms after surgery?
  • Can physical and/or cognitive therapy improve surgical recovery and outcomes?
  • How prevalent are suicidal thoughts and tendencies among the Chiari population and how can those patients be helped?

Goal

Minimize the impact of Chiari on patients and their families, by maximizing patients’ physical, mental, emotional, vocational, recreational, and interpersonal quality of life.

Projects (3)

Active Projects (2)

Career Development Experiences of Individuals with Chiari Malformation | $16,670
Dr. David Tokar

Dr. David Tokar will build on the data collected through the Chiari 1000 to study the impact of Chiari on employment and careers.

Non-invasive Therapies for the Treatment of Chronic Pain in Chiari | $129,973
Dr. Phil Allen

Dr. Allen, along with Dr. Johnson and Dr. Otterstetter, will compare two type of interventions for Chiari patients dealing with chronic pain. Specifically, they will compare a controlled, water based exercise program with a specific type of cognitive therapy.

Completed Projects (1)

The Developmental and Psychoeducational Impact of Chiari Malformation | $53,000
Dr. Kevin Kaut

Dr. Kevin Kaut, a professor in the Psychology Department at the University of Akron, and a former school psychologist is examining in depth the impact Chiari has on school age children and adolescents. Specifically, Dr. Kaut will interview and assess Chiari patients in different age groups to gather data on their cognitive abilities and school experiences. By scientifically examining how Chiari affects children in school, Dr. Kaut believes he can then develop materials and guides for both parents and school officials to maximize Chiari children's participation in the school environment.

A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects.
August 18, 2017

Houston JR, Eppelheimer MS, Pahlavian SH, Biswas D, Urbizu A, Martin BA, Bapuraj JR, Luciano M, Allen PA, Loth F.
J Neuroradiol

Link to Abstract: PMID 28826656

Cerebrospinal fluid velocity amplitudes within the cerebral aqueduct in healthy children and patients with Chiari I malformation.
August, 2016

Bapuraj JR, Londy FJ, Delavari N, Maher CO, Garton HJ, Martin BA, Muraszko KM, Ibrahim el-SH, Quint DJ.
J Magn Reson Imaging

Link to Abstract: PMID 26788935

Cephalometric oropharynx and oral cavity analysis in CM1: a retrospective case controlled study
May 6, 2016

Urbizu A, Ferré A, Poca MA, Rovira A, Sahuquillo J, Martin BA, Macaya A.
JNS

Link to Abstract: PMID 27153161


Accuracy of 4D Flow Measurement of Cerebrospinal Fluid Dynamics in the Cervical Spine:
An In Vitro Verification Against Numerical Simulation

April 4th, 2016

Heidari Pahlavian S, Bunck AC, Thyagaraj S, Giese D, Loth F, Hedderich DM, Kröger JR, Martin BA.
Ann Biomed Eng

Link to Abstract: PMID 27043214


Cough-Associated Changes in CSF Flow in Chiari I Malformation Evaluated by Real-Time MRI
December 24, 2015

Bhadelia RA, Patz S, Heilman C, Khatami D, Kasper E, Zhao Y, Madan N.
AJNR

Link to Abstract: PMID 26705321

Neural Tissue Motion Impacts Cerebrospinal Fluid Dynamics at the Cervical Medullary Junction:
A Patient-Specific Moving-Boundary Computational Model.

December, 2015

Pahlavian SH, Loth F, Luciano M, Oshinski J, Martin BA.
Ann Biomed Eng

Link to Abstract: PMID 26108203


Exercise-induced respondent changes of CSF vascular endothelial growth factor in adult chronic hydrocephalus patients
October 21st, 2015

Yang J., Shanahan K. J. , Shriver L.P. , Luciano M.G.
J Clin Neurosci

Link to Abstract: PMID 26498093

Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine.
October 7, 2015

Martin BA, Yiallourou TI, Pahlavian SH, Thyagaraj S, Bunck AC, Loth F, Sheffer DB, Kröger JR, Stergiopulos N.
Ann Biomed Eng

Link to Abstract: PMID 26446009


Patient-reported Chiari malformation type I symptoms and diagnostic experiences: a report from the national Conquer Chiari Patient Registry database.
May 14, 2015

Fischbein R, Saling JR, Marty P, Kropp D, Meeker J, Amerine J, Chyatte MR.
Neurol Sci

Link to Abstract: PMID 25972139

Characterization of the discrepancies between four-dimensional phase-contrast magnetic resonance imaging and in-silico simulations of cerebrospinal fluid dynamics.
February 20, 2015

Heidari Pahlavian S, Bunck AC, Loth F, Shane Tubbs R, Yiallourou T, Kroeger JR, Heindel W, Martin BA.
J Biomech Eng

Link to Abstract: PMID 25647090


The Impact of Chiari Malformation on Daily Activities: A Report from the National Conquer Chiari Patient Registry Database
January 31, 2015

James Meeker MA, Jenna Amerine MPH, CHES, Denise Kropp BS, CCRP, Michelle Chyatte DrPH, MPH, Rebecca Fischbein, PhD
Disability and Health Journal

Link to Abstract: PMID 24362680

Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics
June 25th, 2014

Markunas CA, Lock E, Soldano K, Cope H, Ding CK, Enterline DS, Grant G, Fuchs H, Ashley-Koch AE, Gregory SG.
BMC Med Genomics

Link to Abstract: PMID 24962150

Cerebrospinal fluid flow impedance is elevated in Type I Chiari malformation
May 30th, 2014

Shaffer N, Martin BA, Rocque B, Madura C, Wieben O, Iskandar BJ, Dombrowski S, Luciano M, Oshinski JN, Loth F
Journal of biomechanical engineering

Link to Abstract: PMID 24362680

Task-specific and general cognitive effects in Chiari malformation type I
April 16th, 2014

Allen PA, Houston JR, Pollock JW, Buzzelli C, Li X, Harrington AK, Martin BA, Loth F, Lien MC, Maleki J, Luciano MG
PloS one

Link to Abstract: PMID 24736676

The impact of spinal cord nerve roots and denticulate ligaments on cerebrospinal fluid dynamics in the cervical spine
April 8th, 2014

Heidari Pahlavian S, Yiallourou T, Tubbs RS, Bunck AC, Loth F, Goodin M, Raisee M, Martin BA
PloS one

Link to Abstract: PMID 24710111

Hydrodynamic and longitudinal impedance analysis of cerebrospinal fluid dynamics at the craniovertebral junction in type I Chiari malformation
October 16th, 2013

Martin BA, Kalata W, Shaffer N, Fischer P, Luciano M, Loth F
PloS one

Link to Abstract: PMID 24130704

Where do we stand on the relationship between tau biomarkers and mild cognitive impairment?
September 16th, 2013

Martin BA, Allen PA
Quantitative imaging in medicine and surgery

Link to Abstract: PMID 24040613

Physiology-based MR imaging assessment of CSF flow at the foramen magnum with a valsalva maneuver
September 2013

Bhadelia RA, Madan N, Zhao Y, Wagshul ME, Heilman C, Butler JP, Patz S.
AJNR Am J Neuroradiol.

Link to Abstract: PMID 23620074

The Chiari Symptom Profile: development and validation of a Chiari-/syringomyelia-specific questionnaire
August 2013

Mueller DM, Oro' JJ.
J Neurosci Nurs.

Link to Abstract: PMID 23812050

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers
February 19th, 2013

Yiallourou TI, Odier C, Heinzer R, Hirt L, Martin BA, Stergiopulos N, Haba-Rubio J
Sleep & breathing = Schlaf & Atmung

Link to Abstract: PMID 22434361

Comparison of 4D phase-contrast MRI flow measurements to computational fluid dynamics simulations of cerebrospinal fluid motion in the cervical spine
January 3rd, 2013

Yiallourou TI, Kröger JR, Stergiopulos N, Maintz D, Martin BA, Bunck AC
PloS one

Link to Abstract: PMID 23284970

Magnetic resonance 4D flow analysis of cerebrospinal fluid dynamics in Chiari I malformation with and without syringomyelia
August 6th, 2012

Bunck AC, Kroeger JR, Juettner A, Brentrup A, Fiedler B, Crelier GR, Martin BA, Heindel W, Maintz D, Schwindt W, Niederstadt T
European radiology

Link to Abstract: PMID 22569996

Ventricle equilibrium position in healthy and normal pressure hydrocephalus brains using an analytical model
June 6th, 2012

Shahim K, Drezet JM, Martin BA, Momjian S
Journal of biomechanical engineering

Link to Abstract: PMID 22667682

A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system
April 2nd, 2012

Martin BA, Reymond P, Novy J, Balédent O, Stergiopulos N
American journal of physiology. Heart and circulatory physiology

Link to Abstract: PMID 22268106

Cerebrospinal fluid hydrodynamics in type I Chiari malformation
April 25th, 2011

Shaffer N, Martin B, Loth F
Neurological research

Link to Abstract: PMID 21513645